Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15230345 | 0.97 | CYP19A1 (0.37) | CYP19A1IRAK4SUV39H2DGAT1NPC1 | |
| Hydrochloric Acid SCHEMBL15230492 | 0.96 | CYP19A1 (0.36) | CYP19A1IRAK4SUV39H2DGAT1NPC1 | |
| Hypochlorous Acid SCHEMBL21485993 | 0.96 | CYP19A1 (0.40) | CYP19A1SUV39H2DGAT1NPC1TP53 | |
| SCHEMBL16782218 | 0.94 | CYP19A1 (0.39) | CYP19A1SUV39H2DGAT1NPC1TP53 | |
| Hydrochloric Acid SCHEMBL15228343 | 0.93 | CYP19A1 (0.39) | CYP19A1SUV39H2DGAT1NPC1TP53 | |
| SCHEMBL15230883 | 0.90 | NPC1 (0.46) | CYP19A1IRAK4SUV39H2NPC1TP53 | |
| Hypochlorous Acid SCHEMBL21486023 | 0.85 | CYP19A1 (0.36) | CYP19A1SUV39H2DGAT1NPC1TP53 | |
| Hypochlorous Acid SCHEMBL21486083 | 0.85 | CYP19A1 (0.36) | CYP19A1SUV39H2DGAT1NPC1TP53 | |
| SCHEMBL15243927 | 0.84 | CYP19A1 (0.38) | CYP19A1DGAT1NPC1TP53HPGD | |
| SCHEMBL15228368 | 0.84 | CYP19A1 (0.40) | CYP19A1DGAT1NPC1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2819519-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2019-10-23 | — | — | EP | claimed |