Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 17/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.71 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.71 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.66 |
| ▸ | KDM1A | O60341 | 13/20 | 0.65 |
| ▸ | RCOR1 | Q9UKL0 | 12/20 | 0.65 |
| ▸ | NSD2 | O96028 | 1/20 | 0.61 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.60 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.60 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21486528 | 0.89 | EHMT2 (0.81) | EHMT2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL21486534 | 0.86 | EHMT2 (0.68) | EHMT2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL21499929 | 0.86 | EHMT2 (0.83) | EHMT2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL21486538 | 0.84 | DNMT3A (0.74) | EHMT2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL21486577 | 0.83 | EHMT2 (0.97) | EHMT2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL21486685 | 0.83 | HDAC1 (1.00) | EHMT2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL21486544 | 0.83 | HDAC1 (1.00) | EHMT2HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL15280227 | 0.79 | EHMT2 (1.00) | EHMT2KDM1ARCOR1EZH2PRMT1 | |
| SCHEMBL14941045 | 0.78 | EHMT2 (0.88) | EHMT2EHMT1KDM1ARCOR1EZH2 | |
| SCHEMBL14940889 | 0.77 | EHMT2 (0.77) | EHMT2HDAC1HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190322643-A1 | HISTONE DEACETYLASE AND HISTONE METHYLTRANSFERASE INHIBITORS AND METHODS OF MAKING AND USE OF THE SAME | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322643-A1 | HISTONE DEACETYLASE AND HISTONE METHYLTRANSFERASE INHIBITORS AND METHODS OF MAKING AND USE OF THE SAME | HDAC1, HDAC2, DOT1L | EHMT2 4/4885HDAC1 1/4885HDAC6 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.