Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 1.00 |
| ▸ | EHMT2 | Q96KQ7 | 12/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 6/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 6/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 5/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 1.00 |
| ▸ | EHMT1 | Q9H9B1 | 5/20 | 1.00 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 5/20 | 0.58 |
| ▸ | RCOR1 | Q9UKL0 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21486685 | 1.00 | HDAC1 (1.00) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21486577 | 0.98 | EHMT2 (0.97) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21499929 | 0.91 | EHMT2 (0.83) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21486545 | 0.90 | EHMT2 (1.00) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21486698 | 0.89 | EHMT2 (1.00) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21486541 | 0.89 | EHMT2 (1.00) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21486596 | 0.87 | EHMT2 (0.97) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21486537 | 0.83 | EHMT2 (0.71) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL31351258 | 0.81 | EHMT2 (0.81) | HDAC1EHMT2HDAC6HDAC3HDAC2 | |
| SCHEMBL21499814 | 0.79 | EHMT2 (0.81) | HDAC1EHMT2HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190322643-A1 | HISTONE DEACETYLASE AND HISTONE METHYLTRANSFERASE INHIBITORS AND METHODS OF MAKING AND USE OF THE SAME | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322643-A1 | HISTONE DEACETYLASE AND HISTONE METHYLTRANSFERASE INHIBITORS AND METHODS OF MAKING AND USE OF THE SAME | HDAC1, HDAC2, DOT1L | HDAC1 1/4885EHMT2 4/4885HDAC6 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.