Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6041432 | 0.86 | RAB9A (0.45) | HRH3ALDH1A1NPC1RAB9AATM | |
| SCHEMBL5200432 | 0.86 | RAB9A (0.45) | TLR2TLR1HRH3ALDH1A1NPC1 | |
| SCHEMBL4328689 | 0.86 | RAB9A (0.45) | TLR2TLR1HRH3ALDH1A1NPC1 | |
| SCHEMBL27708147 | 0.86 | RAB9A (0.45) | TLR2TLR1HRH3ALDH1A1NPC1 | |
| SCHEMBL23923863 | 0.84 | MYC (0.49) | TLR2TLR1SLC6A3SLC6A4HRH3 | |
| SCHEMBL6127033 | 0.84 | MYC (0.49) | TLR2TLR1SLC6A3SLC6A4HRH3 | |
| SCHEMBL6127038 | 0.84 | MYC (0.49) | TLR2TLR1SLC6A3SLC6A4HRH3 | |
| SCHEMBL17514137 | 0.83 | CYP1A2 (0.43) | TLR2TLR1NPC1RAB9AMAPT | |
| SCHEMBL23924236 | 0.82 | TLR2 (0.46) | TLR2TLR1SLC6A3HRH3KDM1A | |
| SCHEMBL15397583 | 0.82 | KDM1A (0.50) | TLR2TLR1SLC6A3SLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |