Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.72 |
| ▸ | HPGDS | O60760 | 8/20 | 0.72 |
| ▸ | F2 | P00734 | 2/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.55 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.55 |
| ▸ | F10 | P00742 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701334 | 1.00 | SMYD3 (0.72) | SMYD3HPGDSF2PRSS1PRSS2 | |
| SCHEMBL21561324 | 0.88 | SMYD3 (0.63) | SMYD3HPGDSDRD4KDM4E | |
| SCHEMBL24360439 | 0.88 | SMYD3 (0.62) | SMYD3HPGDSF2PRSS1PRSS2 | |
| SCHEMBL24360441 | 0.88 | SMYD3 (0.62) | SMYD3HPGDSF2PRSS1PRSS2 | |
| Hydrochloric Acid SCHEMBL27207691 | 0.86 | SMYD3 (0.61) | SMYD3HPGDSF2PRSS1PRSS2 | |
| SCHEMBL6455626 | 0.85 | SMYD3 (0.69) | SMYD3PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL6455623 | 0.85 | SMYD3 (0.69) | SMYD3PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL21489994 | 0.84 | SMYD3 (1.00) | SMYD3HPGDSDRD4 | |
| SCHEMBL19710314 | 0.84 | SMYD3 (1.00) | SMYD3HPGDSDRD4 | |
| SCHEMBL21490004 | 0.82 | SMYD3 (1.00) | SMYD3F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | claimed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | SMYD3 1/4885HPGDS 2697/4885F2 4791/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | SMYD3 2/4885HPGDS 1827/4885F2 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.