Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | GRM5 | P41594 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6455623 | 1.00 | SMYD3 (0.69) | SMYD3ALDH1A1TSHRNPC1GRM5 | |
| SCHEMBL2468483 | 0.93 | NPC1 (0.71) | SMYD3ALDH1A1TSHRNPC1GRM5 | |
| SCHEMBL1667825 | 0.87 | RAB9A (0.73) | ALDH1A1TSHRNPC1GRM5RAB9A | |
| SCHEMBL11241115 | 0.86 | RAB9A (0.75) | ALDH1A1TSHRNPC1GRM5RAB9A | |
| SCHEMBL21489786 | 0.85 | SMYD3 (0.72) | SMYD3PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL19701334 | 0.85 | SMYD3 (0.72) | SMYD3PRSS1PRSS2PRSS3ST14 | |
| SCHEMBL3663354 | 0.84 | ALDH1A1 (0.61) | SMYD3ALDH1A1TSHRNPC1GRM5 | |
| SCHEMBL29530916 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TSHRNPC1GRM5RAB9A | |
| SCHEMBL30098987 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TSHRNPC1GRM5RAB9A | |
| SCHEMBL1711687 | 0.84 | ALDH1A1 (0.63) | ALDH1A1TSHRNPC1GRM5RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | SMYD3 929/4885ALDH1A1 2036/4885TSHR 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.