Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701288 | 1.00 | ALDH1A1 (0.57) | ALDH1A1GAAMAPTHDAC8RAB9A | |
| SCHEMBL6083899 | 0.86 | HDAC8 (0.55) | ALDH1A1GAAMAPTHDAC8RAB9A | |
| SCHEMBL6083909 | 0.86 | HDAC8 (0.55) | ALDH1A1GAAMAPTHDAC8RAB9A | |
| SCHEMBL22449386 | 0.86 | HDAC8 (0.58) | ALDH1A1GAAMAPTHDAC8RAB9A | |
| SCHEMBL3457004 | 0.86 | HDAC8 (0.58) | ALDH1A1GAAMAPTHDAC8RAB9A | |
| SCHEMBL21489764 | 0.84 | SMYD3 (0.64) | ALDH1A1GAAMAPTHDAC8SMYD3 | |
| SCHEMBL19710463 | 0.84 | SMYD3 (0.64) | ALDH1A1GAAMAPTHDAC8SMYD3 | |
| SCHEMBL62928 | 0.83 | HDAC8 (0.55) | ALDH1A1GAAMAPTHDAC8RAB9A | |
| SCHEMBL17595041 | 0.83 | HDAC8 (0.55) | ALDH1A1GAAMAPTHDAC8RAB9A | |
| SCHEMBL21490057 | 0.82 | SMN1; SMN2 (0.52) | ALDH1A1MAPTRAB9ASMN1; SMN2SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | claimed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | ALDH1A1 1575/4885GAA 1370/4885MAPT 3568/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | ALDH1A1 1125/4885GAA 1705/4885MAPT 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.