Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 8/20 | 0.74 |
| ▸ | TNKS | O95271 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.47 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19710047 | 1.00 | SMYD3 (0.74) | SMYD3TNKSCHRNA7CNR2SMN1; SMN2 | |
| SCHEMBL30102646 | 0.85 | SMYD3 (0.68) | SMYD3TNKSCHRNA7CNR2SMN1; SMN2 | |
| SCHEMBL19710384 | 0.85 | SMYD3 (1.00) | SMYD3TNKSCHRNA7POLBAPEX1 | |
| SCHEMBL21490183 | 0.85 | SMYD3 (1.00) | SMYD3TNKSCHRNA7POLBAPEX1 | |
| SCHEMBL1382081 | 0.79 | PARP1 (0.67) | SMYD3TNKSCHRNA7CNR2SMN1; SMN2 | |
| SCHEMBL602081 | 0.78 | SMYD3 (0.58) | SMYD3TNKSCHRNA7CNR2 | |
| SCHEMBL24512945 | 0.77 | SMYD3 (0.58) | SMYD3TNKSCHRNA7CNR2SMN1; SMN2 | |
| SCHEMBL29665814 | 0.77 | SMYD3 (0.58) | SMYD3TNKSCHRNA7CNR2SMN1; SMN2 | |
| SCHEMBL13490630 | 0.76 | SMYD3 (0.56) | SMYD3TNKSCHRNA7CNR2SMN1; SMN2 | |
| SCHEMBL7423976 | 0.75 | SMYD3 (0.58) | SMYD3CNR2SMN1; SMN2FAAHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | claimed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | SMYD3 1/4885TNKS 3237/4885CHRNA7 4717/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | SMYD3 2/4885TNKS 3718/4885CHRNA7 4700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.