Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148867 | 0.85 | AURKA (0.47) | AURKAGSK3BSRCAURKBNTRK1 | |
| SCHEMBL2148630 | 0.84 | AURKA (0.32) | AURKAGSK3BSRCAURKBNTRK1 | |
| SCHEMBL2148586 | 0.82 | AURKA (0.36) | AURKAGSK3BSRCAURKBNTRK1 | |
| SCHEMBL2153217 | 0.81 | SRC (0.44) | AURKAGSK3BSRCAURKBNTRK1 | |
| SCHEMBL2203289 | 0.80 | AURKA (0.47) | AURKAGSK3BSRCAURKBNTRK1 | |
| SCHEMBL2148693 | 0.77 | AURKA (0.56) | AURKAAURKB | |
| SCHEMBL2153735 | 0.75 | AURKA (0.52) | AURKAAURKB | |
| SCHEMBL2159843 | 0.74 | AURKA (0.43) | AURKAGSK3BSRCAURKBNTRK1 | |
| SCHEMBL2148756 | 0.72 | AURKB (0.46) | AURKAGSK3BSRCAURKB | |
| SCHEMBL2948567 | 0.71 | AURKB (0.64) | AURKAGSK3BSRCAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |