Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 8/20 | 0.33 |
| ▸ | CA1 | P00915 | 7/20 | 0.33 |
| ▸ | CA9 | Q16790 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9859212 | 0.90 | APP (0.38) | APPCA2CA1CA9LMNA | |
| SCHEMBL28560570 | 0.90 | CA1 (0.34) | APPCA2CA1CA9LMNA | |
| SCHEMBL29170917 | 0.87 | APP (0.42) | APPCA2CA1CA9LMNA | |
| SCHEMBL11979583 | 0.83 | APP (0.42) | APPCA2CA1CA9LMNA | |
| SCHEMBL27498636 | 0.82 | CA1 (0.48) | CA2CA1CA9LMNAALDH1A1 | |
| SCHEMBL29104749 | 0.81 | APP (0.44) | APPLMNABLMPTGS1PDE4A | |
| SCHEMBL27583722 | 0.80 | APP (0.37) | APPCA2CA1CA9LMNA | |
| SCHEMBL51852 | 0.80 | — | — | |
| SCHEMBL28479330 | 0.79 | CA2 (0.33) | CA2CA1CA9LMNAALDH1A1 | |
| SCHEMBL27583866 | 0.78 | CA2 (0.35) | APPCA2CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190321334-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA | PRESBYOPIA THERAPIES, INC. | 2019-10-24 | — | — | US | disclosed |
| WO-2019204401-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA | PRESBYOPIA THERAPIES LLC (US) | 2019-10-24 | — | — | WO | disclosed |