Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 10/20 | 0.44 |
| ▸ | LIMK2 | P53671 | 10/20 | 0.44 |
| ▸ | TESK2 | Q96S53 | 6/20 | 0.44 |
| ▸ | TESK1 | Q15569 | 5/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484795 | 0.79 | CCNE1 (0.67) | KDM4EMEN1ALDH1A1KMT2ACCNE1 | |
| SCHEMBL21495022 | 0.74 | ADORA2A (0.50) | KDM4EMEN1ALDH1A1KMT2AACP1 | |
| SCHEMBL21484796 | 0.74 | ADORA2A (0.55) | KDM4EMEN1ALDH1A1KMT2APTGS2 | |
| SCHEMBL20353923 | 0.74 | SMN1; SMN2 (0.56) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL21578016 | 0.74 | KDM4E (0.60) | KDM4EMEN1ALDH1A1KMT2APTGS2 | |
| SCHEMBL28518148 | 0.72 | LIMK1 (0.51) | LIMK1LIMK2TESK2TESK1CCNE1 | |
| SCHEMBL25682848 | 0.71 | CSNK1D (0.51) | LIMK1LIMK2TESK2TESK1CCNE1 | |
| SCHEMBL21505742 | 0.69 | CSNK2A1 (0.52) | KDM4EMEN1ALDH1A1KMT2AALOX15 | |
| SCHEMBL6374561 | 0.67 | ACP1 (0.58) | MEN1ALDH1A1KMT2ACDK5ACP1 | |
| SCHEMBL21495032 | 0.67 | LIMK1 (0.55) | ALDH1A1LIMK1LIMK2TESK2TESK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | MASARYKOVA UNIVERZITA (CZ) | 2023-02-21 | — | — | US | disclosed |
| US-20220002282-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2022-01-06 | — | — | US | disclosed |
| CN-112313229-A | Substituted aminothiazoles as inhibitors of nucleases | 马萨里克大学 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019201865-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019201865-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | MASARYKOVA UNIVERZITA (CZ) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | RNASEH1, DNASE1, FEN1 | KDM4E 1848/4885MEN1 1727/4885ALDH1A1 2267/4885 |
| US-20220002282-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES | RNASEH1, DNASE1, FEN1 | KDM4E 1848/4885MEN1 1727/4885ALDH1A1 2267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.