Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 7/20 | 0.63 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.63 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.63 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.63 |
| ▸ | ASPH | Q12797 | 2/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | TPH1 | P17752 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29721741 | 0.87 | KCNQ2 (0.83) | KCNQ2KCNQ3KCNQ4KCNQ5ASPH | |
| SCHEMBL21501784 | 0.87 | KCNQ2 (0.83) | KCNQ2KCNQ3KCNQ4KCNQ5ASPH | |
| SCHEMBL17749067 | 0.82 | KCNQ2 (0.75) | KCNQ2KCNQ3KCNQ4KCNQ5ASPH | |
| SCHEMBL15347739 | 0.77 | KCNQ2 (0.60) | KCNQ2KCNQ3KCNQ4KCNQ5PPARA | |
| SCHEMBL23701891 | 0.76 | KCNQ2 (0.59) | KCNQ2KCNQ3KCNQ4KCNQ5PPARA | |
| SCHEMBL21496311 | 0.75 | KCNQ2 (0.53) | KCNQ2KCNQ3KCNQ4KCNQ5ASPH | |
| SCHEMBL27728996 | 0.75 | FFAR1 (0.55) | KCNQ2KCNQ3ASPHKDM8PPARA | |
| SCHEMBL19690431 | 0.72 | FFAR1 (0.58) | KCNQ2KCNQ3ASPHKDM8PPARA | |
| SCHEMBL20641727 | 0.71 | KCNQ2 (0.57) | KCNQ2KCNQ3KCNQ4KCNQ5ASPH | |
| SCHEMBL24246362 | 0.71 | KCNQ2 (0.75) | KCNQ2KCNQ3KCNQ4KCNQ5ASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-06-14 | — | — | US | disclosed |
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-08-05 | — | — | US | disclosed |
| WO-2019203951-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | KCNH3, KCNH2, KCNJ11 | KCNQ2 35/4885KCNQ3 43/4885KCNQ4 48/4885 |
| US-11358930-B2 | Selective potassium channel agonists | KCNH3, KCNH2, KCNJ11 | KCNQ2 35/4885KCNQ3 43/4885KCNQ4 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.