Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 13/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30054864 | 1.00 | IDO1 (0.58) | IDO1EPHX2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL21496549 | 1.00 | IDO1 (0.58) | IDO1EPHX2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL21496552 | 0.86 | IDO1 (0.73) | IDO1EPHX2MEN1MAPTKMT2A | |
| SCHEMBL21496551 | 0.86 | IDO1 (0.73) | IDO1EPHX2MEN1MAPTKMT2A | |
| SCHEMBL24118231 | 0.86 | IDO1 (0.75) | IDO1LMNANPSR1 | |
| SCHEMBL30056080 | 0.86 | IDO1 (0.75) | IDO1LMNANPSR1 | |
| SCHEMBL30055221 | 0.86 | IDO1 (0.75) | IDO1LMNANPSR1 | |
| SCHEMBL24118077 | 0.86 | IDO1 (0.75) | IDO1LMNANPSR1 | |
| SCHEMBL30056965 | 0.86 | IDO1 (0.74) | IDO1MEN1KMT2ARAB9A | |
| SCHEMBL21504262 | 0.84 | IDO1 (0.61) | IDO1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781142-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204180-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | claimed |