Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 14/20 | 0.73 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496551 | 1.00 | IDO1 (0.73) | IDO1EPHX2MAPTRECQLMEN1 | |
| SCHEMBL30056167 | 0.92 | IDO1 (0.74) | IDO1EPHX2MAPTRECQLMEN1 | |
| SCHEMBL21496364 | 0.89 | IDO1 (0.73) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL23572598 | 0.89 | IDO1 (0.73) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL21496365 | 0.89 | IDO1 (0.73) | IDO1MAPTRECQLMEN1CYP1A2 | |
| SCHEMBL30057673 | 0.89 | IDO1 (0.76) | IDO1MAPTMEN1KMT2ALMNA | |
| SCHEMBL24118278 | 0.89 | IDO1 (0.76) | IDO1MAPTMEN1KMT2ALMNA | |
| SCHEMBL30056965 | 0.88 | IDO1 (0.74) | IDO1MEN1KMT2A | |
| SCHEMBL21496550 | 0.86 | IDO1 (0.58) | IDO1EPHX2MAPTMEN1KMT2A | |
| SCHEMBL21496549 | 0.86 | IDO1 (0.58) | IDO1EPHX2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781142-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204180-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | claimed |