Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.33 |
| ▸ | BRS3 | P32247 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496707 | 0.89 | HDAC11 (0.71) | HDAC11HDAC8 | |
| SCHEMBL21496718 | 0.89 | HDAC11 (0.56) | HDAC11HDAC8BRS3 | |
| SCHEMBL21496710 | 0.76 | HDAC11 (0.54) | HDAC11HDAC8 | |
| SCHEMBL21496660 | 0.75 | HDAC11 (0.79) | HDAC11HDAC8GPR52PARP1 | |
| SCHEMBL21496856 | 0.74 | HDAC11 (0.82) | HDAC11HDAC8 | |
| SCHEMBL23751098 | 0.73 | HDAC11 (0.45) | HDAC11HDAC8 | |
| SCHEMBL21500631 | 0.72 | HDAC11 (0.73) | HDAC11HDAC8 | |
| SCHEMBL30038142 | 0.72 | HDAC11 (0.73) | HDAC11HDAC8 | |
| SCHEMBL21496751 | 0.72 | HDAC11 (1.00) | HDAC11HDAC8 | |
| SCHEMBL21496702 | 0.72 | HDAC11 (0.81) | HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784654-A1 | ISOINDOLINES AS HDAC INHIBITORS | Valo Early Discovery, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019204550-A1 | ISOINDOLINES AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |