Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.82 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496702 | 0.90 | HDAC11 (0.81) | HDAC11HDAC8HCRTR1HCRTR2PTGES | |
| SCHEMBL30038777 | 0.90 | HDAC11 (1.00) | HDAC11HDAC8HCRTR1HCRTR2 | |
| SCHEMBL21496751 | 0.90 | HDAC11 (1.00) | HDAC11HDAC8HCRTR1HCRTR2 | |
| SCHEMBL21500611 | 0.83 | HDAC11 (0.87) | HDAC11HDAC8 | |
| SCHEMBL28512020 | 0.83 | HDAC11 (0.58) | HDAC11HDAC8PTGESPIM1PIM2 | |
| SCHEMBL30038545 | 0.83 | HDAC11 (0.87) | HDAC11HDAC8 | |
| SCHEMBL30038142 | 0.74 | HDAC11 (0.73) | HDAC11HDAC8 | |
| SCHEMBL21500631 | 0.74 | HDAC11 (0.73) | HDAC11HDAC8 | |
| SCHEMBL21496653 | 0.74 | HDAC11 (0.56) | HDAC11HDAC8 | |
| SCHEMBL21500636 | 0.73 | HDAC11 (0.60) | HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784654-A1 | ISOINDOLINES AS HDAC INHIBITORS | Valo Early Discovery, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019204550-A1 | ISOINDOLINES AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |