Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496688 | 1.00 | RIPK1 (0.65) | RIPK1 | |
| SCHEMBL19207590 | 0.92 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL25875210 | 0.90 | RIPK1 (0.62) | RIPK1 | |
| SCHEMBL19255132 | 0.85 | RIPK1 (0.58) | RIPK1 | |
| SCHEMBL29014311 | 0.84 | RIPK1 (0.56) | RIPK1 | |
| SCHEMBL19207688 | 0.84 | RIPK1 (0.56) | RIPK1 | |
| SCHEMBL25240551 | 0.81 | RIPK1 (0.64) | RIPK1 | |
| SCHEMBL25240556 | 0.81 | RIPK1 (0.64) | RIPK1 | |
| Eclitasertib SCHEMBL19207480 | 0.81 | RIPK1 (0.77) | RIPK1 | |
| Eclitasertib SCHEMBL19207477 | 0.81 | RIPK1 (0.77) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126864-A1 | RIP1K INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021203011-A1 | RIP1K INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2021-10-07 | — | — | WO | disclosed |
| EP-3781571-A1 | N-[4-OXO-2,3-DIHYDRO-1,5-BENZOXAZEPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL E-2-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RIP1 KINASE INHIBITORS FOR TREATING E.G. IRRITABLE BOWEL SYNDROME (IBS) | F. Hoffmann-La Roche AG (CH) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204537-A1 | N-[4-OXO-2,3-DIHYDRO-1,5-BENZOXAZEPIN-3-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL E-2-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RIP1 KINASE INHIBITORS FOR TREATING E.G. IRRITABLE BOWEL SYNDROME (IBS) | GENENTECH, INC. (US) | 2019-10-24 | — | — | WO | disclosed |