Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.80 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.80 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20132855 | 0.89 | HDAC11 (1.00) | HDAC11HDAC8NPY5R | |
| SCHEMBL30468600 | 0.89 | HDAC11 (1.00) | HDAC11HDAC8NPY5R | |
| SCHEMBL21496730 | 0.89 | HDAC11 (0.81) | HDAC11HDAC8NPY5REGLN1 | |
| SCHEMBL21496686 | 0.81 | HDAC11 (0.69) | HDAC11HDAC8 | |
| SCHEMBL28511639 | 0.75 | HDAC11 (0.58) | HDAC11HDAC8EGLN1HCRTR1HCRTR2 | |
| SCHEMBL21496790 | 0.71 | HDAC11 (0.47) | HDAC11HDAC8NPY5REGLN1HRH4 | |
| SCHEMBL30039395 | 0.70 | HDAC11 (0.88) | HDAC11HDAC8 | |
| SCHEMBL21496844 | 0.70 | HDAC11 (0.88) | HDAC11HDAC8 | |
| SCHEMBL21496689 | 0.70 | HDAC11 (0.70) | HDAC11HDAC8 | |
| SCHEMBL21496660 | 0.70 | HDAC11 (0.79) | HDAC11HDAC8HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784654-A1 | ISOINDOLINES AS HDAC INHIBITORS | Valo Early Discovery, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019204550-A1 | ISOINDOLINES AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |