Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496789 | 0.71 | HDAC11 (0.80) | HDAC11HDAC8NPY5REGLN1HRH4 | |
| SCHEMBL14690446 | 0.67 | HRH4 (0.60) | EGLN1HRH4NPBWR1KCNH2SCN10A | |
| SCHEMBL21496730 | 0.64 | HDAC11 (0.81) | HDAC11HDAC8NPY5REGLN1ADRA1A | |
| SCHEMBL20132855 | 0.64 | HDAC11 (1.00) | HDAC11HDAC8NPY5R | |
| SCHEMBL30468600 | 0.64 | HDAC11 (1.00) | HDAC11HDAC8NPY5R | |
| SCHEMBL12280690 | 0.63 | NPY5R (0.52) | NPY5RADRA1AKCNH2 | |
| SCHEMBL12280688 | 0.62 | NPY5R (0.51) | NPY5R | |
| SCHEMBL29153822 | 0.62 | SCN10A (0.49) | EGLN1HRH4NPBWR1KCNH2SCN10A | |
| SCHEMBL2421049 | 0.62 | NPY5R (0.63) | NPY5RNPBWR1ADRA1AKCNH2 | |
| SCHEMBL12281042 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784654-A1 | ISOINDOLINES AS HDAC INHIBITORS | Valo Early Discovery, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019204550-A1 | ISOINDOLINES AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |