Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.38 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496909 | 0.87 | PTGER4 (0.46) | PTGER4FSCN1TMEM97SIGMAR1PTGDR2 | |
| SCHEMBL21496918 | 0.85 | PTGER4 (0.43) | PTGER4FSCN1TMEM97SIGMAR1PTGDR2 | |
| SCHEMBL30602807 | 0.79 | PTGER4 (0.44) | PTGER4IDO1FSCN1PTGER1PTGDR2 | |
| SCHEMBL30602808 | 0.77 | CNR1 (0.40) | PTGER4IDO1FSCN1PTGER1 | |
| SCHEMBL17183859 | 0.76 | PIK3R1 (0.40) | PTGER4IDO1FSCN1PTGER1 | |
| SCHEMBL17608381 | 0.75 | ELANE (0.46) | PTGER4PTGDR2HDAC6HDAC3HDAC1 | |
| SCHEMBL1216862 | 0.72 | CYP1A2 (0.51) | PTGER4PTGER1PTGDR2MCL1 | |
| SCHEMBL21512931 | 0.70 | RORC (0.37) | PTGER4TMEM97SIGMAR1PTGDR2 | |
| SCHEMBL24149122 | 0.70 | ELANE (0.56) | PTGER4HDAC6HDAC8MCL1 | |
| SCHEMBL25347539 | 0.70 | PTGER4 (0.72) | PTGER4FSCN1CPT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019204505-A2 | K-RAS MODULATORS WITH A VINYL SULFONAMIDE MOIETY | THERAS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
| WO-2019204505-A2 | K-RAS MODULATORS WITH A VINYL SULFONAMIDE MOIETY | THERAS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |