Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23984749 | 0.70 | KEAP1 (0.58) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL31358814 | 0.70 | KEAP1 (0.66) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL21496939 | 0.69 | KEAP1 (0.44) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL6219389 | 0.68 | KEAP1 (0.64) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL9973783 | 0.68 | PDPK1 (0.67) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL31203422 | 0.67 | KEAP1 (0.47) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL30136593 | 0.66 | KEAP1 (0.64) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL761721 | 0.66 | KEAP1 (0.64) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL23985232 | 0.65 | HDAC1 (0.59) | PDPK1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL24897838 | 0.65 | KEAP1 (0.58) | PDPK1HDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781550-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | Tempest Therapeutics, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204523-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |