Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.68 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | GBA1 | P04062 | 1/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.68 |
| ▸ | PRKCG | P05129 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23671979 | 1.00 | ESR1 (1.00) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| Iodide SCHEMBL30559876 | 0.99 | ESR1 (1.00) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL9452012 | 0.92 | ESR1 (0.84) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL4752564 | 0.90 | ESR1 (0.82) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL4752565 | 0.90 | ESR1 (0.82) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL6947496 | 0.88 | ESR1 (0.79) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL6948715 | 0.88 | ESR1 (0.79) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL6946928 | 0.87 | ESR1 (0.82) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL16579225 | 0.86 | CYP19A1 (0.78) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL84895 | 0.86 | CYP19A1 (0.78) | ESR1CYP19A1CYP3A4ESR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11931366-B2 | Compositions and methods of use thereof for treatment of proteinopathies | WASHINGTON UNIVERSITY (US) | 2024-03-19 | — | — | US | disclosed |
| US-20210228591-A1 | COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATMENT OF PROTEINOPATHIES | WASHINGTON UNIVERSITY | 2021-07-29 | — | — | US | disclosed |
| WO-2019204764-A1 | COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATMENT OF PROTEINOPATHIES | WASHINGTON UNIVERSITY (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11931366-B2 | Compositions and methods of use thereof for treatment of proteinopathies | SERPINA2, FABP1, TTR | ESR1 4834/4885CYP19A1 3711/4885CYP3A4 4382/4885 |
| US-20210228591-A1 | COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATMENT OF PROTEINOPATHIES | SERPINA2, FABP1, TTR | ESR1 4834/4885CYP19A1 3711/4885CYP3A4 4382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.