SCHEMBL6948715

SCHEMBL6948715

CC/C(=C(\c1ccccc1)c1ccc(OCC[N+](C)(C)CBr)cc1)c1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 13/20 0.79
CYP19A1 P11511 7/20 0.64
CYP3A4 P08684 4/20 0.64
ESR2 Q92731 8/20 0.61
MAPT P10636 3/20 0.61
CYP1A2 P05177 2/20 0.61
MEN1 O00255 2/20 0.61
TP53 P04637 2/20 0.61
KMT2A Q03164 2/20 0.61
PSMB1 P20618 2/20 0.61
PSMB5 P28074 2/20 0.61
NPC1 O15118 1/20 0.61
NR1I2 O75469 1/20 0.61
PRKD3 O94806 1/20 0.61
ABCB11 O95342 1/20 0.61
EGFR P00533 1/20 0.61
GBA1 P04062 1/20 0.61
NR3C1 P04150 1/20 0.61
ERBB2 P04626 1/20 0.61
PRKCG P05129 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23671979 0.88 ESR1 (1.00) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL21496962 0.88 ESR1 (1.00) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL6947496 0.87 ESR1 (0.79) ESR1CYP19A1CYP3A4ESR2MAPT
Iodide SCHEMBL30559876 0.87 ESR1 (1.00) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL9452012 0.85 ESR1 (0.84) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL4752565 0.84 ESR1 (0.82) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL4752564 0.84 ESR1 (0.82) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL10796202 0.84 CYP19A1 (0.74) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL7654138 0.84 CYP19A1 (0.74) ESR1CYP19A1CYP3A4ESR2MAPT
SCHEMBL11268363 0.84 CYP19A1 (0.74) ESR1CYP19A1CYP3A4ESR2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0754036-A4 PERMANENTLY IONIC DERIVATIVES OF STEROID HORMONES AND THEIR ANTAGONISTS PHARMOS CORP (US) 2003-03-19 EP disclosed
US-5650425-A ANTICARCINOGENIC, ANTAGONIST, ANTITUMOR AGENTS AND ANTIINFLAMMATORY AGENTS PHARMOS CORPORATION (US) 1997-07-22 US disclosed
EP-0754036-A1 PERMANENTLY IONIC DERIVATIVES OF STEROID HORMONES AND THEIR ANTAGONISTS PHARMOS CORPORATION (US) 1997-01-22 EP disclosed
WO-1995026720-A1 PERMANENTLY IONIC DERIVATIVES OF STEROID HORMONES AND THEIR ANTAGONISTS PHARMOS CORPORATION (US) 1995-10-12 WO disclosed