Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 20/20 | 0.56 |
| ▸ | PDCD1LG2 | Q9BQ51 | 18/20 | 0.56 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23724890 | 0.92 | CD274 (0.57) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL25175600 | 0.92 | CD274 (0.57) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL23727030 | 0.91 | CD274 (0.60) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL25172047 | 0.91 | CD274 (0.60) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL23725822 | 0.84 | CD274 (0.54) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL23725246 | 0.83 | PDCD1 (0.70) | CD274PDCD1 | |
| SCHEMBL23726005 | 0.82 | CD274 (0.53) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL23726118 | 0.82 | CD274 (0.56) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL21496983 | 0.82 | CD274 (0.59) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL21544593 | 0.82 | CD274 (0.59) | CD274PDCD1LG2PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781556-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204609-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |