Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26382167 | 1.00 | PAOX (0.54) | PAOXSMN1; SMN2HTR7GLALMNA | |
| SCHEMBL13168443 | 0.93 | SMN1; SMN2 (0.54) | PAOXSMN1; SMN2GLALMNAALDH1A1 | |
| SCHEMBL12428914 | 0.86 | SMN1; SMN2 (0.62) | PAOXSMN1; SMN2GLALMNAALDH1A1 | |
| SCHEMBL13135991 | 0.81 | PAOX (0.77) | PAOXSMN1; SMN2HTR7GLALMNA | |
| SCHEMBL27055095 | 0.80 | PAOX (0.50) | PAOXSMN1; SMN2HTR7GLALMNA | |
| SCHEMBL30489760 | 0.79 | GLA (0.69) | PAOXSMN1; SMN2HTR7GLALMNA | |
| SCHEMBL5843494 | 0.79 | KDM4E (0.57) | PAOXSMN1; SMN2HTR7GLALMNA | |
| SCHEMBL1194005 | 0.79 | GLA (0.69) | PAOXSMN1; SMN2HTR7GLALMNA | |
| SCHEMBL9150763 | 0.79 | GLA (0.69) | PAOXSMN1; SMN2HTR7GLALMNA | |
| SCHEMBL1726737 | 0.79 | KDM4E (0.57) | PAOXSMN1; SMN2HTR7GLALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | HBG2, HBG1, HBB | PAOX 1181/4885SMN1; SMN2 1207/4885HTR7 2696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.