HBB

Hemoglobin subunit beta · P68871 · HBB on Sugi Atlas →

57,058 patent compounds predicted against HBB, 41,579 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Reserpine Reserpine (SCHEMBL2589) 1.00 5/20
Reserpine Reserpine (SCHEMBL28129) 0.84 5/20
Rescinnamine Rescinnamine (SCHEMBL181966) 0.81 5/20
Thiamiprine Thiamiprine (SCHEMBL4851) 0.71 5/20
Topotecan Topotecan (SCHEMBL3836) 1.00 3/20
Mercaptopurine Anhydrous Mercaptopurine Anhydrous (SCHEMBL3893) 1.00 3/20
Topotecan Topotecan (SCHEMBL7247) 1.00 3/20
Topotecan Topotecan (SCHEMBL7248) 1.00 3/20
Topotecan Topotecan (SCHEMBL10278) 1.00 3/20
Quinacrine Quinacrine (SCHEMBL19225) 1.00 3/20
Quinacrine Quinacrine (SCHEMBL20205) 1.00 3/20
Quinacrine Quinacrine (SCHEMBL33693) 1.00 3/20
Quinacrine Quinacrine (SCHEMBL162378) 1.00 3/20
Quinacrine Quinacrine (SCHEMBL162379) 1.00 3/20
Topotecan Topotecan (SCHEMBL133645) 0.97 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL156584) 0.61 3/20
Thioguanine Thioguanine (SCHEMBL168164) 0.59 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL167869) 0.54 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL167870) 0.54 3/20
Acyclovir Acyclovir (SCHEMBL3175) 1.00 2/20

Clinical trials — most relevant to HBB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Major PHASE4UNKNOWN
Collagen-thrombin Matrix Efficacy During Cardiac Surgery: a Prospective Randomized Controlled Trial PHASE4COMPLETED
Deciphering Effects of Thalidomide on Red Blood Cells in Transfusion Dependents Beta Thalassemia Patients PHASE3COMPLETED
Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia PHASE2/PHASE3COMPLETED
Trial of HQK-1001 in Beta Thalassemia Intermedia in Lebanon PHASE2COMPLETED
Study of SDMB (2,2 Dimethylbutyrate, Sodium Salt) in Beta Thalassemia Intermedia in Thailand PHASE2COMPLETED
The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia PHASE1/PHASE2COMPLETED
Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia PHASE1COMPLETED
Association of Hb F Level With Clinical Severity of Beta Thalassemia nanUNKNOWN
The Prevelence of HBB c.93-21 G-A in β Thalassemia Patients nanUNKNOWN
Thalassaemia Severity nanNOT_YET_RECRUITING
Glucose Metabolism in Sickle Cell Disease nanACTIVE_NOT_RECRUITING
Effect of Aquatic Exercises on Muscle Strength and Quality of Life in Children With Sickle Cell Anemia nanCOMPLETED
HbA2 Leuven and Its Impact on HbA1c Results nanCOMPLETED
Pumilio1 (PUM1) Expression, Sickle Cell Anemia, β-thalassemia Intermedia nanNOT_YET_RECRUITING
Relationship of Haptoglobin Phenotype to Vascular Function and Response to Vitamin E Supplementation in Patients With Diabetes Mellitus Type 2: The EVAS Trial nanUNKNOWN
Assessment of Pain in People With Thalassemia nanCOMPLETED
Detection of Krupple Like Factor -1(KLF1/ EKLF) DNA Mutations in Beta Thalassemia Patients nanNOT_YET_RECRUITING
EKLF Gene Expression in β-thalassemia nanNOT_YET_RECRUITING
Hyperbilirubinemia and Retinopathy of Prematurity in Preterm Infants: a Retrospective Study. nanUNKNOWN
Impact of Dried Moringa Oleifera Leaves in Enhancing Hemoglobin Status nanCOMPLETED
Hepcidin Levels in Sickle Cell Disease (SCD) nanCOMPLETED
Detection Of β-thalassemia Carriers In Assiut nanUNKNOWN
Genetic Variants Affecting the Clinical Severity of Beta Thalassemia nanUNKNOWN
Parvovirus B19 Infection in Hereditary Hemolytic Anemias Patients nanUNKNOWN
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose nanUNKNOWN
Retinal Oximtery Following Treatment for Diabetic Maculopathy nanCOMPLETED
Cohort Study of Sickle Cell Patients Evaluating Analgesic Strategies and Their Consequences nanCOMPLETED
SpHb Perioperatively nanCOMPLETED
The Use of CGMS to Detect Alterations of Blood Glucose in Thalassemic Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HBB binder may also engage these)

ProteinNameSimilarity
P02024 1.000 P02024 →
P13557 1.000 P13557 →
Q6WN25 1.000 Q6WN25 →
P02040 1.000 P02040 →
P68223 1.000 P68223 →
P68232 1.000 P68232 →
P68873 1.000 P68873 →
P68872 1.000 P68872 →
P19885 1.000 P19885 →
P18985 1.000 P18985 →
P02031 1.000 P02031 →
P02059 1.000 P02059 →
P61773 1.000 P61773 →
Q6WN28 1.000 Q6WN28 →
Q03902 1.000 Q03902 →
P02030 1.000 P02030 →
P68064 1.000 P68064 →
P02028 1.000 P02028 →
Q6WN29 1.000 Q6WN29 →
Q6WN26 1.000 Q6WN26 →
Q45XI9 1.000 Q45XI9 →
P08259 1.000 P08259 →
P02033 1.000 P02033 →
Q6WN27 1.000 Q6WN27 →
Q5XLE5 1.000 Q5XLE5 →
P02029 1.000 P02029 →
Q45XJ0 1.000 Q45XJ0 →
P02054 1.000 P02054 →
P60525 1.000 P60525 →
P61775 1.000 P61775 →