Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23479341 | 0.92 | MEN1 (0.38) | NPC1RAB9AGFERF2RL3TRPV1 | |
| SCHEMBL25054111 | 0.79 | NPC1 (0.47) | NPC1RAB9AGFERF2RL3TRPV1 | |
| SCHEMBL761133 | 0.78 | ALDH1A1 (0.45) | NPC1RAB9ATRPV1MEN1KMT2A | |
| SCHEMBL19262922 | 0.74 | SCN10A (0.38) | MEN1KMT2APDE10APOLBNTRK1 | |
| SCHEMBL28876443 | 0.74 | NPC1 (0.46) | NPC1RAB9AGFERF2RL3TRPV1 | |
| SCHEMBL30358398 | 0.74 | NPC1 (0.46) | NPC1RAB9AGFERF2RL3TRPV1 | |
| SCHEMBL11337498 | 0.74 | NPC1 (0.47) | NPC1RAB9AGFERF2RL3TRPV1 | |
| SCHEMBL22330400 | 0.74 | SCN10A (0.37) | MEN1KMT2APDE10APOLBNTRK1 | |
| SCHEMBL21341477 | 0.72 | GAA (0.52) | NPC1RAB9AGFERF2RL3TRPV1 | |
| SCHEMBL13265535 | 0.72 | ALDH1A1 (0.40) | NPC1RAB9AF2RL3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472342-B2 | Compounds and compositions for inhibition of FASN | FORMA THERAPEUTICS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-10450286-B2 | Compounds and compositions for inhibition of FASN | FORMA THERAPEUTICS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472342-B2 | Compounds and compositions for inhibition of FASN | FASN, FABP1, SCD | NPC1 369/4885RAB9A 2916/4885GFER 723/4885 |
| US-10450286-B2 | Compounds and compositions for inhibition of FASN | FASN, FABP1, SCD | NPC1 369/4885RAB9A 2916/4885GFER 723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.