Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 4/20 | 0.68 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.68 |
| ▸ | KCNQ4 | P56696 | 4/20 | 0.68 |
| ▸ | KCNQ5 | Q9NR82 | 4/20 | 0.68 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.32 |
| ▸ | CDK2 | P24941 | 7/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | GPR6 | P46095 | 1/20 | 0.30 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21501782 | 0.89 | KCNQ2 (0.54) | KCNQ3KCNQ2KCNQ4KCNQ5MAP4K1 | |
| SCHEMBL21501783 | 0.89 | KCNQ2 (0.54) | KCNQ3KCNQ2KCNQ4KCNQ5MAP4K1 | |
| SCHEMBL23711068 | 0.87 | KCNQ3 (0.62) | KCNQ3KCNQ2KCNQ4KCNQ5MAP4K1 | |
| SCHEMBL21501781 | 0.84 | KCNQ2 (0.63) | KCNQ3KCNQ2KCNQ4KCNQ5CYP2D6 | |
| SCHEMBL29721771 | 0.83 | KCNQ2 (0.70) | KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL21501772 | 0.83 | KCNQ2 (0.70) | KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL23711128 | 0.76 | KCNQ3 (0.50) | KCNQ3KCNQ2KCNQ4KCNQ5MAP4K1 | |
| SCHEMBL23711096 | 0.76 | KCNQ3 (0.50) | KCNQ3KCNQ2KCNQ4KCNQ5MAP4K1 | |
| SCHEMBL21501779 | 0.72 | KCNQ2 (0.59) | KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL21501775 | 0.72 | KCNQ2 (0.59) | KCNQ3KCNQ2KCNQ4KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358930-B2 | Selective potassium channel agonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-06-14 | — | — | US | disclosed |
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-08-05 | — | — | US | disclosed |
| WO-2019203951-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238129-A1 | SELECTIVE POTASSIUM CHANNEL AGONISTS | KCNH3, KCNH2, KCNJ11 | KCNQ3 43/4885KCNQ2 35/4885KCNQ4 48/4885 |
| US-11358930-B2 | Selective potassium channel agonists | KCNH3, KCNH2, KCNJ11 | KCNQ3 43/4885KCNQ2 35/4885KCNQ4 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.