Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 10/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA5A | P35218 | 1/20 | 0.63 |
| ▸ | CA7 | P43166 | 1/20 | 0.63 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21325661 | 0.85 | GLS (0.70) | GLSHSD17B10ESR1POLBALOX15 | |
| SCHEMBL20392398 | 0.84 | TP53 (0.59) | GLSHSD17B10ESR1POLBALOX15 | |
| SCHEMBL20340835 | 0.84 | GLS (0.86) | GLS | |
| SCHEMBL28162550 | 0.83 | GLS (0.71) | GLSHSD17B10CA1CA2CA5A | |
| SCHEMBL21360273 | 0.83 | GLS (0.67) | GLS | |
| SCHEMBL8834375 | 0.82 | GLS (1.00) | GLSPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL19454383 | 0.82 | GLS (1.00) | GLSHSD17B10CA1CA2CA5A | |
| SCHEMBL7483330 | 0.81 | GLS (0.81) | GLSHSD17B10CA1CA2CA5A | |
| SCHEMBL28162551 | 0.81 | GLS (0.77) | GLS | |
| SCHEMBL12027279 | 0.81 | GLS (0.77) | GLSPOLBNPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3556757-A1 | CYCLOALKYL-LINKED DIHETEROCYCLE DERIVATIVES | Pfizer Inc (US) | 2019-10-23 | — | — | EP | disclosed |