Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 7/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166671 | 0.86 | EPHX1 (0.39) | BCHETRPV1OPRK1OPRD1 | |
| SCHEMBL2150429 | 0.84 | BCHE (0.36) | BCHETRPV1 | |
| SCHEMBL15576267 | 0.83 | BCHE (0.36) | BCHETRPV1OPRK1OPRD1 | |
| SCHEMBL2150626 | 0.83 | ITGB1 (0.38) | BCHEOPRK1OPRD1 | |
| SCHEMBL2150631 | 0.83 | ITGB1 (0.38) | BCHEOPRK1OPRD1 | |
| SCHEMBL3131903 | 0.77 | KMT2A (0.39) | BCHEKDM4E | |
| SCHEMBL27840640 | 0.76 | MTNR1A (0.45) | BCHEKDM4ENPC1RAB9AGFER | |
| SCHEMBL1710752 | 0.76 | BCHE (0.38) | BCHEKDM4E | |
| SCHEMBL2151073 | 0.76 | EPHX1 (0.42) | BCHENPC1OPRK1OPRD1 | |
| SCHEMBL2797442 | 0.75 | EPHX1 (0.36) | BCHEOPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340242-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-06 | — | — | EP | disclosed |
| WO-2010048332-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-04-29 | — | — | WO | disclosed |