Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30613862 | 1.00 | PIK3CD (0.41) | PIK3CDOPRK1PDE10AAAK1ADORA2A | |
| SCHEMBL29968837 | 0.91 | OPRK1 (0.36) | PIK3CDOPRK1PDE10AAAK1ADORA2A | |
| SCHEMBL26132097 | 0.86 | OPRK1 (0.38) | OPRK1 | |
| SCHEMBL29968894 | 0.86 | OPRK1 (0.38) | OPRK1 | |
| SCHEMBL21513454 | 0.82 | OPRK1 (0.36) | OPRK1JAK2JAK1 | |
| SCHEMBL21513420 | 0.81 | PDE10A (0.38) | PIK3CDOPRK1PDE10AAAK1ADORA2A | |
| SCHEMBL29969620 | 0.81 | PDE10A (0.38) | PIK3CDOPRK1PDE10AAAK1ADORA2A | |
| SCHEMBL26128335 | 0.78 | OPRK1 (0.34) | OPRK1PIK3CAJAK2JAK1 | |
| SCHEMBL29969605 | 0.78 | AAK1 (0.37) | OPRK1PDE10AAAK1ADORA2AADORA2B | |
| SCHEMBL26130733 | 0.76 | OPRK1 (0.37) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |