Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 9/20 | 0.45 |
| ▸ | PRKDC | P78527 | 4/20 | 0.45 |
| ▸ | MTOR | P42345 | 9/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.37 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SERPINA2 | P20848 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968839 | 1.00 | ATM (0.45) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL29968542 | 0.82 | PRKDC (0.45) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL21513499 | 0.82 | PRKDC (0.45) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL21513256 | 0.81 | NPC1 (0.45) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL29968579 | 0.81 | MTOR (0.49) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL21513255 | 0.81 | MTOR (0.49) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL29968928 | 0.81 | NPC1 (0.45) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL21513498 | 0.81 | ATM (0.46) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21513497 | 0.81 | ATM (0.42) | ATMPRKDCMTORPIK3CAPIK3C2A | |
| SCHEMBL29969092 | 0.81 | ATM (0.46) | ATMPRKDCMTORPIK3CAATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |