Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | FEN1 | P39748 | 5/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29969696 | 1.00 | ALOX5AP (0.44) | ALOX5APFEN1IDO1TDO2JAK3 | |
| SCHEMBL26130336 | 0.83 | HSD17B10 (0.34) | IDO1JAK3KDM4EHSD17B10 | |
| SCHEMBL26590176 | 0.83 | IDO1 (0.39) | ALOX5APFEN1IDO1TDO2JAK3 | |
| SCHEMBL29968865 | 0.83 | IDO1 (0.39) | ALOX5APFEN1IDO1TDO2JAK3 | |
| SCHEMBL29308759 | 0.81 | ALOX5AP (0.44) | ALOX5APFEN1IDO1TDO2JAK3 | |
| SCHEMBL12801074 | 0.81 | USP30 (0.44) | ALOX5APFEN1USP30NR1H2NAMPT | |
| SCHEMBL14828895 | 0.79 | FNTA (0.38) | ALOX5APFEN1IDO1TDO2JAK3 | |
| SCHEMBL14829207 | 0.78 | IDO1 (0.38) | ALOX5APFEN1IDO1TDO2JAK3 | |
| SCHEMBL31207480 | 0.78 | DGAT1 (0.47) | ALOX5APFEN1IDO1TDO2USP30 | |
| SCHEMBL22247188 | 0.78 | DGAT1 (0.47) | ALOX5APFEN1IDO1TDO2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |