Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23030074 | 0.81 | ALDH1A1 (0.50) | MAPTKDM4EALDH1A1HPGDGLA | |
| SCHEMBL29231836 | 0.81 | ALDH1A1 (0.50) | MAPTKDM4EALDH1A1HPGDGLA | |
| SCHEMBL30550015 | 0.79 | MAPT (0.45) | MAPTKDM4ECYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL25375277 | 0.79 | MAPT (0.45) | MAPTKDM4ECYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21515083 | 0.79 | CYP3A4 (0.48) | MAPTKDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30550091 | 0.78 | MAPT (0.44) | MAPTKDM4ECYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL25371822 | 0.78 | MAPT (0.44) | MAPTKDM4ECYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21515048 | 0.75 | SMN1; SMN2 (0.49) | MAPTKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL25372139 | 0.74 | MAPT (0.49) | MAPTKDM4ECYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL30549945 | 0.74 | MAPT (0.49) | MAPTKDM4ECYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781554-B1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FOER MEDICINSK FORSKNING (SE) | 2023-06-28 | — | — | EP | disclosed |
| WO-2019201991-A1 | 2,6-DIAMINO-3,4-DIHYDROPYRIMIDIN-4-ONE DERIVATIVES AND USE THEREOF IN THERAPY | THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) | 2019-10-24 | — | — | WO | disclosed |