Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NPSR1	Q6W5P4	2/20	0.53

▸	CYP1A2	P05177	3/20	0.47

▸	LMNA	P02545	1/20	0.47

▸	CYP2D6	P10635	1/20	0.47

▸	TSHR	P16473	1/20	0.47

▸	BLM	P54132	1/20	0.47

▸	HIF1A	Q16665	1/20	0.47

▸	MEN1	O00255	3/20	0.46

▸	KMT2A	Q03164	3/20	0.46

▸	NPC1	O15118	2/20	0.42

▸	RAB9A	P51151	2/20	0.42

▸	HTT	P42858	2/20	0.42

▸	POLB	P06746	1/20	0.42

▸	CYP3A4	P08684	2/20	0.41

▸	CYP2C19	P33261	2/20	0.41

▸	FAAH	O00519	1/20	0.40

▸	MGLL	Q99685	1/20	0.40

▸	MAPT	P10636	2/20	0.40

▸	ALOX12	P18054	1/20	0.40

▸	NPY1R	P25929	1/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL21519637	0.91	NPSR1 (0.56)	NPSR1CYP1A2LMNACYP2D6TSHR
Acetic Acid SCHEMBL21519440	0.91	NPSR1 (0.40)	NPSR1CYP1A2LMNACYP2D6TSHR
Acetic Acid SCHEMBL21519631	0.88	KDM1A (0.49)	NPSR1CYP1A2LMNACYP2D6TSHR
Guanabenz SCHEMBL21519448	0.87	CYP1A2 (0.49)	NPSR1CYP1A2LMNACYP2D6TSHR
Acetic Acid SCHEMBL21519585	0.87	CYP1A2 (0.46)	NPSR1CYP1A2LMNACYP2D6TSHR
Acetic Acid SCHEMBL21519649	0.86	SMN1; SMN2 (0.48)	NPSR1MEN1KMT2ANPC1RAB9A
Acetic Acid SCHEMBL21519427	0.86	CYP1A2 (0.45)	NPSR1CYP1A2LMNACYP2D6TSHR
Acetic Acid SCHEMBL21519577	0.85	CYP1A2 (0.44)	NPSR1CYP1A2LMNACYP2D6TSHR
SCHEMBL21537975	0.84	NPSR1 (0.63)	NPSR1CYP1A2LMNAMEN1KMT2A
SCHEMBL21519439	0.84	NPSR1 (0.44)	NPSR1MEN1KMT2AHTTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-12006294-B2	Therapeutic compounds	REGENTS OF THE UNIVERSITY OF MINNESOTA (US)	2024-06-11	—	—	US	disclosed
US-20190330157-A1	THERAPEUTIC COMPOUNDS	REGENTS OF THE UNIVERSITY OF MINNESOTA	2019-10-31	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20190330157-A1	THERAPEUTIC COMPOUNDS	OPRL1, INA, OGFR	NPSR1 82/4885CYP1A2 1407/4885LMNA 1901/4885
US-12006294-B2	Therapeutic compounds	OPRL1, INA, OGFR	NPSR1 82/4885CYP1A2 1407/4885LMNA 1901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.