Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21117960 | 0.93 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDHTTALDH1A1LMNA | |
| SCHEMBL21141592 | 0.92 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTALDH1A1LMNA | |
| SCHEMBL20999873 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTEPHX2ALDH1A1 | |
| SCHEMBL26382038 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTEPHX2ALDH1A1 | |
| SCHEMBL17168743 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTEPHX2ALDH1A1 | |
| SCHEMBL17767812 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTEPHX2ALDH1A1 | |
| SCHEMBL17767809 | 0.92 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDHTTEPHX2ALDH1A1 | |
| SCHEMBL6048384 | 0.88 | FAAH (0.49) | SMN1; SMN2HPGDHTTKDM4EEPHX2 | |
| SCHEMBL6048382 | 0.88 | FAAH (0.49) | SMN1; SMN2HPGDHTTKDM4EEPHX2 | |
| SCHEMBL6048378 | 0.88 | FAAH (0.49) | SMN1; SMN2HPGDHTTKDM4EEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340049-B1 | METHOD OF ACYLATING A PEPTIDE OR PROTEIN | NOVO NORDISK AS (DK) | 2015-11-11 | — | — | EP | disclosed |
| US-8791236-B2 | Method of acylating a peptide or protein | NOVO NORDISK A/S (DK) | 2014-07-29 | — | — | US | disclosed |
| US-20140142280-A1 | Method of Acylating a Peptide or Protein | NOVO NORDISK A/S (DK) | 2014-05-22 | — | — | US | disclosed |
| US-8637647-B2 | Method of acylating a peptide or protein | NOVO NORDISK A/S (DK) | 2014-01-28 | — | — | US | disclosed |
| US-20110213131-A1 | Method of Acylating a Peptide or Protein | NOVO NORDISK A/S (DK) | 2011-09-01 | — | — | US | disclosed |
| EP-2340049-A1 | METHOD OF ACYLATING A PEPTIDE OR PROTEIN | Novo Nordisk A/S (DK) | 2011-07-06 | — | — | EP | disclosed |
| WO-2010029159-A1 | METHOD OF ACYLATING A PEPTIDE OR PROTEIN | NOVO NORDISK A/S (DK) | 2010-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213131-A1 | Method of Acylating a Peptide or Protein | DNPEP, PTMA, ANPEP | SMN1; SMN2 3837/4885HPGD 2211/4885HTT 1315/4885 |
| US-20140142280-A1 | Method of Acylating a Peptide or Protein | DNPEP, PTMA, ANPEP | SMN1; SMN2 3957/4885HPGD 2498/4885HTT 1299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.