Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99181 | 0.87 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP2C19 | |
| SCHEMBL6326388 | 0.87 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4ESMN1; SMN2PARP14 | |
| SCHEMBL5213661 | 0.86 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP2C19 | |
| SCHEMBL5214121 | 0.84 | HSP90AA1 (0.57) | ALDH1A1HPGDKDM4ESMN1; SMN2PARP14 | |
| SCHEMBL13960511 | 0.84 | HDAC1 (0.51) | ALDH1A1HPGDKDM4ESMN1; SMN2PARP14 | |
| SCHEMBL3899331 | 0.84 | CYP2C19 (0.54) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP2C19 | |
| SCHEMBL31500633 | 0.84 | HSP90AA1 (0.57) | ALDH1A1HPGDKDM4ESMN1; SMN2PARP14 | |
| SCHEMBL5106705 | 0.84 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ESMN1; SMN2POLB | |
| SCHEMBL9762630 | 0.83 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4ESMN1; SMN2PARP14 | |
| SCHEMBL3640507 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11771684-B2 | Inhibitors of dihydroceramide desaturase for treating disease | CENTAURUS THERAPEUTICS (US) | 2023-10-03 | — | — | US | disclosed |
| US-11135207-B2 | Inhibitors of dihydroceramide desaturase for treating disease | CENTAURUS THERAPEUTICS (US) | 2021-10-05 | — | — | US | disclosed |
| US-20190328720-A1 | INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE | CENTAURUS THERAPEUTICS | 2019-10-31 | — | — | US | disclosed |
| CN-102060790-B | Quinoxaline double N-oxide derivative ligand and application thereof in promotion on copper-catalyzed C-O coupling reaction | SHANGHAI INST TECHNOLOGY | 2013-01-09 | — | — | CN | disclosed |
| CN-102060790-A | Quinoxaline double N-oxide derivative ligand and application thereof to promotion on copper-catalyzed C-O coupling reaction | SHANGHAI INST TECHNOLOGY | 2011-05-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11771684-B2 | Inhibitors of dihydroceramide desaturase for treating disease | CERS2, DEGS1, SMPD1 | ALDH1A1 647/4885HPGD 975/4885KDM4E 4599/4885 |
| US-11135207-B2 | Inhibitors of dihydroceramide desaturase for treating disease | CERS2, DEGS1, SMPD1 | ALDH1A1 647/4885HPGD 975/4885KDM4E 4599/4885 |
| US-20190328720-A1 | INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE | CERS2, DEGS1, SMPD1 | ALDH1A1 647/4885HPGD 975/4885KDM4E 4599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.