Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14718046 | 0.94 | HTR6 (0.39) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL14717737 | 0.93 | HTR6 (0.44) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL14719195 | 0.92 | HTR6 (0.38) | HTR6DRD1NPY5R | |
| SCHEMBL14718876 | 0.91 | HTR6 (0.43) | HTR6MMP2MMP9 | |
| SCHEMBL14719141 | 0.89 | HTR6 (0.38) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL14718595 | 0.89 | HTR6 (0.46) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL2153296 | 0.88 | HTR6 (0.37) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL14718466 | 0.88 | HTR6 (0.44) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL2153211 | 0.88 | HTR6 (0.41) | HTR6DRD1HTR1AHTR2AHTR7 | |
| SCHEMBL2153426 | 0.87 | HTR6 (0.38) | HTR6DRD1HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519527-A1 | THIENO [2,3-B]PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | Poxel (FR) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080277-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | POXEL (FR) | 2011-07-07 | — | — | WO | claimed |
| EP-2519527-A1 | THIENO [2,3-B]PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | Poxel (FR) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080277-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | POXEL (FR) | 2011-07-07 | — | — | WO | disclosed |