Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 7/20 | 0.69 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.69 |
| ▸ | PGR | P06401 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189267 | 0.87 | GRIA1 (0.78) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189567 | 0.86 | GRIA1 (0.55) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189441 | 0.85 | GRIA1 (0.74) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189581 | 0.83 | GRIA1 (0.76) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189631 | 0.83 | GRIA1 (1.00) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL20111124 | 0.81 | GRIA1 (0.70) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL1460047 | 0.80 | GRIA1 (0.64) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189376 | 0.80 | GRIA1 (0.64) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189619 | 0.79 | GRIA1 (0.72) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL28203387 | 0.78 | GRIA1 (0.70) | GRIA1CACNG8PGRBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |