Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 8/20 | 0.70 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.70 |
| ▸ | PGR | P06401 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189619 | 0.92 | GRIA1 (0.72) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189476 | 0.88 | GRIA1 (0.82) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189441 | 0.86 | GRIA1 (0.74) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189631 | 0.84 | GRIA1 (1.00) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189267 | 0.83 | GRIA1 (0.78) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189405 | 0.82 | GRIA1 (0.70) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL21533151 | 0.78 | GRIA1 (0.69) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189650 | 0.78 | GRIA1 (0.86) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL20111135 | 0.77 | GRIA1 (0.79) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189592 | 0.77 | GRIA1 (0.76) | GRIA1CACNG8PGRBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107750250-A | Indolone compounds and their use as ampa receptor modulators | 詹森药业有限公司 | 2018-03-02 | — | — | CN | claimed |
| CN-107750250-A | Indolone compounds and their use as ampa receptor modulators | 詹森药业有限公司 | 2018-03-02 | — | — | CN | disclosed |