Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21535638 | 1.00 | KDM4E (0.38) | KDM4EATMALDH1A1MEN1GLA | |
| SCHEMBL19995958 | 0.75 | PDE4B (0.43) | KDM4EALDH1A1MEN1GAAMAPT | |
| SCHEMBL27522260 | 0.74 | ALDH1A1 (0.37) | KDM4EATMALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL4757290 | 0.71 | MAPK1 (0.36) | KDM4EALDH1A1GAAMAPTMAPK1 | |
| SCHEMBL7431818 | 0.71 | ALDH1A1 (0.39) | KDM4EATMALDH1A1MEN1GLA | |
| SCHEMBL5584941 | 0.69 | HTR2C (0.47) | KDM4EALDH1A1MEN1GAAMAPT | |
| SCHEMBL19382042 | 0.69 | MAPK1 (0.34) | KDM4EALDH1A1MEN1GLAGAA | |
| SCHEMBL15830146 | 0.68 | KDM4E (0.54) | KDM4EATM | |
| SCHEMBL10212349 | 0.68 | KDM4E (0.54) | KDM4EATM | |
| SCHEMBL17864290 | 0.68 | MAPK1 (0.34) | KDM4EALDH1A1MEN1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233858-B1 | ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2019-10-30 | — | — | EP | disclosed |