Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23561274 | 0.90 | ALDH1A1 (0.41) | BCHENOTUMALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL21569636 | 0.88 | BCHE (0.45) | BCHENOTUMALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL21535957 | 0.86 | BCHE (0.45) | BCHEALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL18745372 | 0.83 | BCHE (0.41) | BCHENOTUMALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL18626574 | 0.83 | BCHE (0.41) | BCHENOTUMALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL13515726 | 0.80 | SMN1; SMN2 (0.49) | BCHEALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL19176855 | 0.79 | BCHE (0.49) | BCHENOTUMPOLBGAAPKM | |
| SCHEMBL8016072 | 0.75 | RXFP1 (0.43) | BCHENOTUMALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL21042359 | 0.73 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2KDM4ETSHRHSD17B10 | |
| SCHEMBL24777622 | 0.73 | BCHE (0.49) | BCHENOTUMALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10464947-B2 | Tricyclic heterocycles as BET protein inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2019-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10464947-B2 | Tricyclic heterocycles as BET protein inhibitors | BRD1, BRD3, BRD2 | BCHE 3135/4885NOTUM 3538/4885ALDH1A1 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.