SCHEMBL21539902

SCHEMBL21539902

O=C(c1ccccc1)c1ccc(CN2C(=O)c3ccccc3C2(CO)c2ccc(Cl)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 20/20 0.58
TP53 P04637 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21539904 0.85 MDM2 (0.63) MDM2TP53
SCHEMBL12305425 0.84 MDM2 (0.82) MDM2
SCHEMBL1828449 0.84 MDM2 (0.82) MDM2
SCHEMBL20100158 0.83 MDM2 (0.62) MDM2TP53
SCHEMBL12305427 0.79 MDM2 (0.86) MDM2TP53
SCHEMBL2459432 0.79 MDM2 (0.86) MDM2TP53
SCHEMBL1819470 0.74 MDM2 (1.00) MDM2
SCHEMBL20100134 0.73 MDM2 (0.76) MDM2TP53
SCHEMBL2459937 0.73 MDM2 (1.00) MDM2TP53
SCHEMBL7989560 0.73 MDM2 (1.00) MDM2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2960233-B1 NEW THERAPEUTIC AGENTS CANCER RESEARCH TECH LTD (GB) 2019-10-30 EP disclosed