Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21539942 | 0.84 | MDM2 (0.41) | MDM2HPGDLMNAALDH1A1FFAR1 | |
| SCHEMBL21539910 | 0.84 | MAPT (0.41) | MDM2HPGDALDH1A1FFAR1TP53 | |
| SCHEMBL17366171 | 0.76 | MDM2 (0.49) | MDM2HPGDLMNAALDH1A1TP53 | |
| SCHEMBL20100175 | 0.66 | MDM2 (0.44) | MDM2ALDH1A1TP53MAPT | |
| SCHEMBL27246030 | 0.64 | TDP1 (0.44) | MDM2HPGDLMNAALDH1A1CA12 | |
| SCHEMBL21539815 | 0.61 | HPGD (0.41) | MDM2HPGDLMNAALDH1A1TP53 | |
| SCHEMBL2453711 | 0.60 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL7997320 | 0.60 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL30121977 | 0.59 | MDM2 (0.64) | MDM2HPGDLMNAALDH1A1TP53 | |
| SCHEMBL17962620 | 0.59 | HPGD (0.46) | MDM2HPGDLMNAALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960233-B1 | NEW THERAPEUTIC AGENTS | CANCER RESEARCH TECH LTD (GB) | 2019-10-30 | — | — | EP | disclosed |