Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.88 |
| ▸ | MAOB | P27338 | 4/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzonitrile SCHEMBL27895262 | 1.00 | TSHR (0.88) | TSHRMAOBMAOACYP2A6ALDH1A1 | |
| Benzonitrile SCHEMBL27793280 | 0.94 | TSHR (1.00) | TSHRMAOBMAOACYP2A6ALDH1A1 | |
| Benzonitrile SCHEMBL30929383 | 0.94 | TSHR (1.00) | TSHRMAOBMAOACYP2A6ALDH1A1 | |
| Benzonitrile SCHEMBL2153738 | 0.94 | TSHR (1.00) | TSHRMAOBMAOACYP2A6ALDH1A1 | |
| Benzonitrile SCHEMBL27363057 | 0.94 | TSHR (1.00) | TSHRMAOBMAOACYP2A6ALDH1A1 | |
| Benzonitrile SCHEMBL6640 | 0.94 | — | — | |
| Benzonitrile SCHEMBL11044747 | 0.94 | — | — | |
| Benzonitrile SCHEMBL9464940 | 0.94 | TSHR (1.00) | TSHRMAOBMAOACYP2A6ALDH1A1 | |
| Benzonitrile SCHEMBL21752925 | 0.94 | — | — | |
| Benzonitrile SCHEMBL9576062 | 0.91 | TSHR (0.82) | TSHRMAOBMAOACYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184171-B1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | CHEVRON PHILLIPS CHEMICAL CO LP (US) | 2019-03-20 | — | — | EP | disclosed |
| US-10144752-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2018-12-04 | — | — | US | disclosed |
| CN-106083927-B | Phosphino- amidine compound, metal complex, antigravity system and their oligomeric or olefin polymerization purposes | 切弗朗菲利浦化学公司 | 2018-10-26 | — | — | CN | disclosed |
| US-20170305945-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2017-10-26 | — | — | US | disclosed |
| US-9732106-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2017-08-15 | — | — | US | disclosed |
| EP-3184171-A1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | Chevron Phillips Chemical Company LP (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2519532-B1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | CHEVRON PHILLIPS CHEMICAL CO LP (US) | 2017-03-08 | — | — | EP | disclosed |
| US-20160168180-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2016-06-16 | — | — | US | disclosed |
| US-9283555-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2016-03-15 | — | — | US | disclosed |
| US-20140221645-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-08-07 | — | — | US | disclosed |
| US-8680003-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-03-25 | — | — | US | disclosed |
| US-20120309965-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-12-06 | — | — | US | disclosed |
| EP-2519532-A1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | Chevron Phillips Chemical Company LP (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082192-A1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10144752-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | NIT2, NCLN, NPM1 | TSHR 3542/4885MAOB 2884/4885MAOA 3125/4885 |
| US-20120309965-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | NIT2, NCLN, NPM1 | TSHR 3542/4885MAOB 2884/4885MAOA 3125/4885 |
| US-20160168180-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | NIT2, NCLN, NPM1 | TSHR 3542/4885MAOB 2884/4885MAOA 3125/4885 |
| US-20140221645-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | NIT2, NCLN, NPM1 | TSHR 3542/4885MAOB 2884/4885MAOA 3125/4885 |
| US-20170305945-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | NIT2, NCLN, NPM1 | TSHR 3542/4885MAOB 2884/4885MAOA 3125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.