Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560108 | 0.83 | MAPT (0.58) | CYP1A2CYP2D6MAPTKMT2ANPSR1 | |
| SCHEMBL16094875 | 0.82 | CYP1A2 (0.57) | CYP1A2CYP2D6MAPTKMT2ANPSR1 | |
| SCHEMBL13989245 | 0.79 | MAPT (0.66) | CYP1A2CYP2D6MAPTKMT2ANPSR1 | |
| SCHEMBL856815 | 0.78 | MAPT (0.70) | CYP1A2CYP2D6MAPTKMT2ANPSR1 | |
| SCHEMBL29762330 | 0.78 | MAPT (0.70) | CYP1A2CYP2D6MAPTKMT2ANPSR1 | |
| SCHEMBL31616206 | 0.77 | SYK (0.39) | CYP1A2CYP2D6MAPTKMT2ARAF1 | |
| SCHEMBL855348 | 0.77 | MAPT (0.68) | CYP1A2CYP2D6MAPTKMT2ANPSR1 | |
| SCHEMBL21520311 | 0.76 | CYP17A1 (0.41) | CYP1A2CYP2D6MAPTRAF1BRAF | |
| SCHEMBL1028538 | 0.76 | CYP1A2 (1.00) | CYP1A2CYP2D6MAPTKMT2ARAF1 | |
| SCHEMBL30353341 | 0.76 | CYP1A2 (0.66) | CYP1A2CYP2D6MAPTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654834-B2 | Non-systemic TGR5 agonists | Venenum Biodesign, LLC (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190330191-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | Venenum Biodesign, LLC (US) | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330191-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | GPR119, FFAR1, FFAR3 | CYP1A2 1439/4885CYP2D6 1941/4885MAPT 3811/4885 |
| US-10654834-B2 | Non-systemic TGR5 agonists | GPR119, SSTR5, FFAR3 | CYP1A2 1241/4885CYP2D6 1857/4885MAPT 3667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.