Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | CSF1R | P07333 | 5/20 | 0.37 |
| ▸ | CDK4 | P11802 | 5/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21541845 | 0.97 | PIK3CD (0.38) | PIK3CDCSF1RCDK4CDK6CCNK | |
| SCHEMBL21541846 | 0.91 | KMO (0.39) | KDM1AMETPDE3BPDE3ADYRK1A | |
| SCHEMBL21541808 | 0.90 | S1PR1 (0.37) | CSF1RCDK4CDK6CCNA2CDK2 | |
| SCHEMBL21541749 | 0.89 | CSF1R (0.37) | PIK3CDCSF1RCDK4CDK6CCNK | |
| SCHEMBL21541802 | 0.89 | CSF1R (0.37) | PIK3CDCSF1RCDK4CDK6CCNK | |
| SCHEMBL21541893 | 0.87 | MELK (0.37) | KDM1AMETPDE3BPDE3AMELK | |
| SCHEMBL21541733 | 0.86 | CDK4 (0.37) | CSF1RCDK4CDK6CCNA2CDK2 | |
| SCHEMBL21541904 | 0.86 | PRKDC (0.40) | PIK3CDCSF1RCDK4CDK6CCNK | |
| SCHEMBL21541761 | 0.86 | KCNH2 (0.37) | CDK4CDK6KDM1AMETPDE3B | |
| SCHEMBL21541815 | 0.82 | SYK (0.38) | CDK4CDK6KDM1AMETPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567041-A9 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-04-20 | — | — | EP | disclosed |
| US-10874670-B2 | Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof | IMPACT THERAPEUTICS, INC. (CN) | 2020-12-29 | — | — | US | disclosed |
| EP-3567041-A1 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | Impact Therapeutics, Inc (CN) | 2019-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874670-B2 | Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof | CHEK1, CHEK2, CDK1 | PIK3CD 149/4885CSF1R 2386/4885CDK4 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.