Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 17/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.47 |
| ▸ | ATR | Q13535 | 13/20 | 0.45 |
| ▸ | ATRIP | Q8WXE1 | 13/20 | 0.45 |
| ▸ | ATM | Q13315 | 9/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21541837 | 0.91 | PRKDC (0.47) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL21541721 | 0.90 | PRKDC (0.36) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL30689457 | 0.90 | PRKDC (0.36) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL21541754 | 0.90 | PRKDC (0.48) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL21541738 | 0.88 | PRKDC (0.61) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL21541733 | 0.86 | CDK4 (0.37) | MTORCSF1RCDK4CDK6NOTUM | |
| SCHEMBL21541912 | 0.86 | PRKDC (0.47) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL30689454 | 0.86 | PRKDC (0.47) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL21541806 | 0.84 | PRKDC (0.45) | PRKDCPIK3CBATRATRIPATM | |
| SCHEMBL21541808 | 0.83 | S1PR1 (0.37) | MTORCSF1RCDK4CDK6NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567041-A9 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-04-20 | — | — | EP | disclosed |
| US-10874670-B2 | Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof | IMPACT THERAPEUTICS, INC. (CN) | 2020-12-29 | — | — | US | disclosed |
| EP-3567041-A1 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | Impact Therapeutics, Inc (CN) | 2019-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874670-B2 | Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof | CHEK1, CHEK2, CDK1 | PRKDC 61/4885PIK3CB 89/4885ATR 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.