Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725735 | 1.00 | MAPT (0.72) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL29437403 | 1.00 | MAPT (0.72) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL1392965 | 0.87 | MAPT (0.89) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL2723171 | 0.83 | MAPT (1.00) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL4825456 | 0.83 | MAPT (1.00) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL31072982 | 0.83 | MAPT (0.64) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL5380119 | 0.83 | MAPT (0.64) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL29437400 | 0.83 | MAPT (1.00) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| Hydrochloric Acid SCHEMBL5036857 | 0.82 | MAPT (0.63) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL29742107 | 0.81 | MAPT (0.69) | MAPTRAB9ACHRNB4CHRNA3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567042-A1 | CDK INHIBITORS | G1 Therapeutics, Inc. (US) | 2019-11-13 | — | — | EP | disclosed |