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SCHEMBL2154492

SCHEMBL2154492

CCCCOC1(c2ccccc2C)CN(C(=O)C(Cc2ccc(O)cc2)NC(=O)CCc2cnc[nH]2)C1.CCCCOC1(c2ccccc2C)CN(C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)CC(O)c2c[nH]cn2)C1

nearest known ligand 0.70

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MC1R Q01726 9/20 0.70
▸ MC4R P32245 9/20 0.66
▸ MC5R P33032 1/20 0.42
▸ MC3R P41968 1/20 0.42
▸ ANPEP P15144 1/20 0.33
▸ LNPEP Q9UIQ6 1/20 0.33
▸ P2RY12 Q9H244 1/20 0.33
▸ REN P00797 4/20 0.32
▸ POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20450424 0.90 MC1R (0.65) MC1RMC4RMC5RMC3RP2RY12
SCHEMBL1310203 0.90 MC1R (0.65) MC1RMC4RMC5RMC3RP2RY12
SCHEMBL1309721 0.88 MC1R (0.79) MC1RMC4RMC5RMC3RANPEP
SCHEMBL20450442 0.88 MC1R (0.79) MC1RMC4RMC5RMC3RANPEP
SCHEMBL1310622 0.83 MC1R (0.65) MC1RMC4RMC5RMC3RP2RY12
SCHEMBL20450385 0.83 MC1R (1.00) MC1RMC4RMC5RMC3RP2RY12
SCHEMBL1325753 0.83 MC1R (0.64) MC1RMC4RMC5RMC3RP2RY12
SCHEMBL1310201 0.83 MC1R (0.78) MC1RMC4RMC5RMC3R
SCHEMBL20450360 0.83 MC1R (0.78) MC1RMC4RMC5RMC3R
SCHEMBL1310839 0.83 MC1R (0.78) MC1RMC4RMC5RMC3R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2342194-A1 OXOAZETIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS Galderma Research & Development (FR) 2011-07-13 — — EP disclosed